Hypoxia and exercise performance in fish

Researchers from the Nutrigroup of IATS-CSIC have targeted the mild-hypoxia driving force for metabolic and muscle transcriptional reprogramming of gilthead sea bream juveniles, focusing on blood metabolic landmarks and muscle transcriptomics before and after exhaustive exercise. These results after mild-hypoxia conditioning highlighted an increased contribution of lipid metabolism to whole energy supply to preserve the aerobic energy production, a better swimming performance regardless of changes in feed intake, as well as reduced protein turnover and improved anaerobic fitness with the restoration of normoxia.

The results of this work, funded by National (BreamAquaINTECH; RTI2018–094128-B-I00) and European AQUAEXCEL2020 (Aquaculture infrastructures for excellence in European fish research towards 2020; 652831) Projects, have been published in the special issue Transcriptome and Genome Analyses Applied to Aquaculture Research of the open-access Journal Biology (link).

For more information, visit CSIC Comunidad Valenciana delegation webpage.

Insect larvae meal as a sustainable feed ingredient in aquaculture

A recent collaboration between IATS Nutrigenomics group and CIIMAR from Porto University (Portugal) has highlighted the feasibility of high replacement of fish meal in aquaculture diets with insect-derived meal.

The effect of fish meal replacement by defatted mealworm (Tenebrio molitor) larvae meal in European sea bass aquafeeds was tested, evidencing that it was possible to replace up to 80% of fish meal by insect meal without impairing growth performance, nutrients digestibility and fillet quality.

These results are of special importance for the growing need of environmentally sustainable alternatives to fish meal in aquaculture.

The work has been partly funded by a transnational access (TNA) of H2020 project AQUAEXCEL2020 at IATS infrastructures. It was selected as a relevant output in the Info Day of EATiP at Aquaculture Europe 2019 in Berlin, and it has been recently published in the Open Access journal Frontiers in Physiology.

La genética regula la microbiota de la dorada

Investigadores de los grupos de Nutrigenómica y de Patología de peces del IATS han puesto de relieve cómo la selección genética de la dorada afecta a su microbiota intestinal y a la resistencia a enfermedades.

La composición de la microbiota de familias de doradas seleccionadas por su elevado crecimiento se adaptaba mejor y con menos variaciones a cambios en la dieta que la de doradas seleccionadas por crecimiento bajo. Esta adaptación confirió además una mayor resistencia a la infección de un parásito intestinal.

Estos resultados contribuyen a la mejora en la formulación de piensos sostenibles y los programas de selección génica en acuicultura.

Este trabajo ha sido financiado por el proyecto H2020 AquaIMPACT, el proyecto Nacional Bream-AquaINTECH y el PROGENSA III del programa JACUMAR, y se ha publicado en la revista de Acceso Abierto Microbiome.

Para más información, la delegación del CSIC en la Comunidad Valenciana ha redactado la siguiente nota de prensa.

Nutrigenomics and Pathology groups of IATS at the University of Las Palmas

Researchers of Nutrigenomics and Fish Pathology groups of Institute of Aquaculture Torre de la Sal (IATS-CSIC) performed the second programmed sampling through the production cycle of sea bream to assess the differential effects of new diet formulations on the composition of gut microbiota of fish select for heritable growth.

The study is conducted within the framework of the AquaImpact H2020 EU project, using diets formulated by Skretting and fish from the PROGENSA selection program that are grow-out at the experimental facilities of Ecoaqua at the University of Las Palmas de Gran Canaria (ULPGC).

The expect impact are new insights in the regulation and plasticity of fish gut microbiota with local and systemic effects on a wide-range of biological processes.

All the operations are made following the contingency plan of COVID19.

Paula Simó-Mirabet doctorates

Paula has presented by video-conference during the Covid confinement her PhD Thesis at the Autonomous University of Barcelona. The study entitled “MOLECULAR AND FUNCTIONAL ANALYSIS OF SIRTUINS AS METABOLIC MARKERS IN SEABREAM  was conducted at the Institute of Aquaculture Torre de la Sal (IATS) with Dr. Jaume Pérez-Sánchez (Nutrigenómics and Fish Endocrinology group) as  PhD Director.

Congratulations Paula!

Paula has actively participated in National (Mi2-Fish, Progensa III) and European projects (ARRAINA, PerformFish). Paula also collaborated with the IATS Pathology group, and she is co-author of more than 20 peer-reviewed articles. She has more than 10 contributions in International Congress of Fish Nutrition, Physiology and Endocrinology.

Good luck!

The success story of AQUAEXCEL2020 at 2019

The Institute of Aquaculture has participated actively on AQUAEXCEL2020 at 2019.

Researchers of Fish Pathology and Nutrigenomics groups participated on two face to face training courses: Planning and conducting experimental infection trials in fish & Fish nutrition and feeding

Four out of seven Project catalogues presented in the Info Day of EATiP of EAS Berlin 2019 were from IATS-CSIC.

The eighth AQUAEXCEL2020 newsletter has been released. It includes the Transnational Access (TNA) Success Stories section, with a focus on the productive TNA project Disrupting effects of plasticizers in sea bream conducted at IATS-CSIC.

CSIC published four AQUAEXCEL2020 articles of high Scientific impact on 2019:

Perez-Sánchez et al.,2019. Frontiers in Marine Science 6: 760

Peixoto et al., 2019. Scientific Reports 9: 16134

Forner-Piquer et al., International Journal of Molecular Sciences 20:5003

Sitjà-Bobadilla et al., 2019. Parasites & Vectors 12:486.

Epigenetic regulation of sirt1 in gilthead sea bream

Researchers from the Nutrigroup of IATS-CSIC have described the gene organization of the seven gilthead sea bream sirtuins, a family of proteins considered as master regulators of energy metabolism from bacteria to higher vertebrates. The study evidences the tissue-specific regulation of each sirtuin with the contribution of epigenetic mechanisms in the regulation of sirt-1 at the level of skeletal muscle.

The results of this work,  funded by National (BreamAquaINTECH; RTI2018–094128-B-I00) and European (PerformFISH; H2020-SFS-2016-2017, 727610) Projects, have been published in the Open-access Journal Frontiers in Zoology (link).

 

Broodstock nutrition can shape scd1a gene expression in the gilthead sea bream offspring

Researchers from the Nutrigroup of IATS-CSIC and  IU-ECOAQUA of Las Palmas de Gran Canaria University have evaluated the effects of linolenic acid (ALA) broodstock nutrition in the offspring of gilthead sea bream. The study revealed the epigenetic regulation of Δ9 fatty acid desaturase (scd1a), involving changes in the DNA-methylation of scd1a promoter close to SP1 and HNF4α binding sites.

The phenotypic output is a reduced offspring scd1a expression, limiting the lipogenic activity and the risk of hepatic steatosis with a reduced supply of n-3 LC-PUFA.

The results of this work, funded by EU Project PerformFISH (Integrating  Innovative  Approaches  for  Competitive  and Sustainable Performance across the Mediterranean Aquaculture Value Chain; H2020-SFS-2016-2017, 727610), have been published in Epigenetics (link).

AQUAEXCEL2020 TNA stay

PhD student Federico Moroni, from the Department of Biotechnologies and Life Science of University of Insubria (Italy) has completed an AQUAEXCEL2020 TNA stay with IATS-Nutrigroup.

The LABFORTIFEEDBREAM TNA is aimed to assess the beneficial effects of feeds fortification with lactic acid bacteria on the growth and intestinal health of cultured gilthead sea bream. Effects on growth and performance will be complemented with transcriptomic analysis of key genes of growth and metabolism, as well as intestinal microbiome characterization. Results will be useful to evaluate the use of lactic acid bacterial not only in gilthead sea bream but also in other marine fish species.

POSTDOCTORAL CONTRACT JUAN DE LA CIERVA-FORMACIÓN (Nutrigenomics group)

We are looking for candidates to request a Juan de la Cierva formación contract (see bases here)  to develop a scientific career within the Nutrigenomics and Fish Growth Endocrinology Group (www.nutrigroup-iats.org) led by Dr. Jaume Pérez Sánchez at the Institute of Aquaculture Torre la Sal (IATS- CSIC). The work will be conducted within the framework of National and H2020 EU Projects (PerformFISH AquaIMPACT, AQUAEXCEL3) to characterize phenotypically and functionally the interaction of farmed fish with its environment, using new biotechnological and genomic tools. The expected outcome is to produce more robust and efficient fish by means of integrative approaches based on the use of new few additives, strict criteria of welfare, genetic selection and nutritional/environmental programming.

The candidates should have defended their thesis between January 1st 2018 and the 31st December 2019.

Experience in nutrition, physiology, molecular biology and bioinformatics will be valued.

Interested candidates contact Dr. Jaume Pérez-Sánchez (jaime.perez.sanchez@csic.es) before the 5 January 2020 including a CV and up to 2 reference letters.