Epigenetic regulation of sirt1 in gilthead sea bream

Researchers from the Nutrigroup of IATS-CSIC have described the gene organization of the seven gilthead sea bream sirtuins, a family of proteins considered as master regulators of energy metabolism from bacteria to higher vertebrates. The study evidences the tissue-specific regulation of each sirtuin with the contribution of epigenetic mechanisms in the regulation of sirt-1 at the level of skeletal muscle.

The results of this work,  funded by National (BreamAquaINTECH; RTI2018–094128-B-I00) and European (PerformFISH; H2020-SFS-2016-2017, 727610) Projects, have been published in the Open-access Journal Frontiers in Zoology (link).