Broodstock nutrition can shape scd1a gene expression in the gilthead sea bream offspring

Researchers from the Nutrigroup of IATS-CSIC and  IU-ECOAQUA of Las Palmas de Gran Canaria University have evaluated the effects of linolenic acid (ALA) broodstock nutrition in the offspring of gilthead sea bream. The study revealed the epigenetic regulation of Δ9 fatty acid desaturase (scd1a), involving changes in the DNA-methylation of scd1a promoter close to SP1 and HNF4α binding sites.

The phenotypic output is a reduced offspring scd1a expression, limiting the lipogenic activity and the risk of hepatic steatosis with a reduced supply of n-3 LC-PUFA.

The results of this work, funded by EU Project PerformFISH (Integrating  Innovative  Approaches  for  Competitive  and Sustainable Performance across the Mediterranean Aquaculture Value Chain; H2020-SFS-2016-2017, 727610), have been published in Epigenetics (link).

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